Embryonic Stem Cells

Hypoxia Pathway

 
 
 
 

 

Oxygen is an essential substrate for bioenergetics, metabolism, and cell survival. Hypoxia refers to a condition in which the oxygen supply of a tissue is reduced, causing a non-physiological level of oxygen tension. Hypoxia is a common phenomenon in ischemia and in a wide range of malignant tumors, leading to dysfunctional tissue restructuring and metastasis. The underlying mechanisms of oxygen homeostasis involve hypoxia inducible factors and other biological processes such as mitochondrial activity, DNA damage, apoptosis, autophagy, and tissue remodeling. The study of hypoxia and its contribution to disease progression will help identify therapeutic targets and tools for timely treatment of diseases such as ischemia and cancer.  At Genuine Biotech, we provide high-quality antibodies and knockdown validated lentiviral shRNAs to help you investigate the biochemical mechanisms of hypoxia.

Hypoxia Response Via HIF Activation

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated AKT Serine/Threonine Kinase 2 Rabbit mAb
1472
Human, mouse, rat
WB
KD-Validated Aryl Hydrocarbon Receptor Nuclear Translocator Rabbit mAb
1657
Human, mouse, rat
WB
KD-Validated Hypoxia Inducible Factor 1 Subunit Alpha Rabbit mAb
3321
Human
WB, IC, F
KD-Validated Mammalian target of rapamycin Rabbit mAb
5756
Human, mouse, pig
WB
KD-Validated Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subun...
9311
Human, mouse
WB
KD-Validated Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subun...
6911
Human
WB
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Rabb...
66342
Human
WB, IHC
Phosphoinositide-3-Kinase Regulatory Subunit 1 Rabbit mAb
66341
Human, mouse
WB, IHC
Phosphatase And Tensin Homolog Rabbit mAb
66725
Human, mouse
WB, IHC