Oxygen is an essential substrate for bioenergetics, metabolism, and cell survival. Hypoxia refers to a condition in which the oxygen supply of a tissue is reduced, causing a non-physiological level of oxygen tension. Hypoxia is a common phenomenon in ischemia and in a wide range of malignant tumors, leading to dysfunctional tissue restructuring and metastasis. The underlying mechanisms of oxygen homeostasis involve hypoxia inducible factors and other biological processes such as mitochondrial activity, DNA damage, apoptosis, autophagy, and tissue remodeling. The study of hypoxia and its contribution to disease progression will help identify therapeutic targets and tools for timely treatment of diseases such as ischemia and cancer.  At Genuine Biotech, we provide high-quality antibodies and knockdown validated lentiviral shRNAs to help you investigate the biochemical mechanisms of hypoxia.