Host Defense Antibodies & ShRNAs
Understanding the immune signaling pathways triggered by SARS-CoV-2 at the site of the viral entry and at systemic level will reveal relevant molecular targets for clinical intervention and management. It is well-documented that SARS-CoV-2 viruses enter host cells through receptor ACE2, triggering a variety of signaling cascades such as NF-κB/TNFα, IL6/JAK/STAT, and sphingosine-1-phosphate receptor 1 (S1P) signaling pathways. We have been using lentiviral shRNA-based platform to knock down genes, and thus their encoded proteins, involved in virus-mediated immune response pathways. These antibodies and their respective gene silencing shRNA lentiviruses have been validated using Western blot, immunocytochemistry-immunofluorescence, or flow cytometry. Use human protein codes in the table to search our website and you will find both antibodies and their respective shRNA lentiviruses.