Image by National Cancer Institute

Host Defense Antibodies & ShRNAs

 
 
 

Understanding the immune signaling pathways triggered by SARS-CoV-2 at the site of the viral entry and at systemic level will reveal relevant molecular targets for clinical intervention and management.  It is well-documented that SARS-CoV-2 viruses enter host cells through receptor ACE2, triggering a variety of signaling cascades such as NF-κB/TNFα, IL6/JAK/STAT, and sphingosine-1-phosphate receptor 1 (S1P) signaling pathways. We have been using lentiviral shRNA-based platform to knock down genes, and thus their encoded proteins, involved in virus-mediated immune response pathways. These antibodies and their respective gene silencing shRNA lentiviruses have been validated using Western blot, immunocytochemistry-immunofluorescence, or flow cytometry. Use human protein codes in the table to search our website and you will find both antibodies and their respective shRNA lentiviruses.

T-Cell Receptor Signaling Pathway

Activation of Innate Immune Response

Response to IL-1

Viral Process

Viral Life Cycle

Viral Entry into Host Cells

Regulation of NIK/NFKB Signaling

Regulation of TNF Production

Regulation of T Cell Activation

Lymphocyte Mediated Immunity 

Regulation of Necrotic Cell Death

Toll Like Receptor Signaling

Negative Regulation of Cytokine Production

Cytokine Production

B Cell Differentiation

Positive Regulation of Programmed Cell Death

Positive Regulation of Innate Immune Response

Regulation of Innate Immune Response

Regulation of Immune Response

Regulation of Cytokine-Mediated Signaling Pathway

Regulation of Cytokine Production

Natural Killer Cell Differentiation

Adaptive Immune Response