Embryonic Stem Cells

Chromatin & Epigenetics

 
 
 
 

The composition and spatial organization of chromatin are critical for the regulation of gene expression in eukaryotes. The local chromatin environment and the high-order chromatin organization not only determine the accessibility of DNA to transcription factors and RNA polymerase, but also define the spatial proximity between the DNA regulatory elements. In recent years epigenetics, a term referring to modification of histone proteins such as methylation-demethylation and acetylation-deacetylation, has received increasing interests, largely because epigenetics has been linked to human diseases, including, but not limited to, autoimmune disease, behavior plasticity, neurodegenerative and psychological disorder, cancer, and addiction. At Genuine Biotech, we provide high-quality antibodies and knockdown validated lentiviral shRNAs to help you investigate the biochemical mechanisms of chromatin organization and epigenetics.

Regulation Of Chromatin Organization

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Catenin Beta 1 Rabbit mAb
1711
Human, mouse, rat
WB, IC, F
KD-Validated Death Domain Associated Protein Rabbit mAb
2188
Human, mouse, rat
WB
KD-Validated Euchromatic Histone Lysine Methyltransferase 2 Rabbit mAb
2352
Human
WB, IC
KD-Validated GATA Binding Protein 3 Rabbit mAb
3173
Human, mouse, rat
IC
KD-Validated Lysine Acetyltransferase 2A Rabbit mAb
4172
Human, mouse, rat, cow, dog, chicken, pig
WB
Lysine Acetyltransferase 7 Rabbit mAb
64177
Human, mouse, rat
WB
Mitogen-Activated Protein Kinase 3 Rabbit mAb
65164
Human, mouse
WB, IHC
Mitogen-Activated Protein Kinase 8 Rabbit mAb
65168
Human
WB
KD-Validated O-GlcNAc Transferase Rabbit mAb
85370
Human, mouse, rat, cow, dog, pig
WB
Ring Finger Protein 20 Rabbit mAb
66520
Human; Mouse; Rat
WB
KD-Validated Ribosomal Protein S6 Kinase A4 Rabbit mAb
6614
Human
IC
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB
KD-Validated Sirtuin 6 Rabbit mAb
7366
Human
IC
KD-Validated SMAD Family Member 4 Rabbit mAb
7524
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F

Histone Deacetylase Activity

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Histone Deacetylase 3 Mouse mAb
3213
Human, mouse, rat, cow, dog
WB, IC
KD-Validated Histone Deacetylase 4 Rabbit mAb
3214
Human, mouse, rat
WB
KD-Validated Histone Deacetylase 7 Rabbit mAb
3217
Human
IC
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB
Sirtuin 2 Rabbit mAb
67362
Human, mouse
WB
KD-Validated Sirtuin 6 Rabbit mAb
7366
Human
IC

Histone-lysine N-methyltransferase Activity

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated ASH2-Like Rabbit mAb
1734
Human, Mouse, Rat
WB, IC
KD-Validated Euchromatic Histone Lysine Methyltransferase 2 Rabbit mAb
2352
Human
WB, IC
KD-Validated Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Rabb...
2932
Human, mouse, rat, cow, dog, chicken, pig
WB, IC
KD-Validated Lysine Methyltransferase 2B Rabbit mAb
4521
Human
WB
KD-Validated Ring Finger Protein 2 Rabbit mAb
6522
Human, mouse, rat
IC
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB

Histone Acetyltransferase Binding

Protein Name
Item name
Catalog No.
Reactivity
Applications
ETS Proto-Oncogene 1, Transcription Factor Rabbit mAb
62771
Human, mouse
WB, IHC
KD-Validated Hypoxia Inducible Factor 1 Subunit Alpha Rabbit mAb
3321
Human
WB, IC, F
Paired Box 6 Rabbit mAb
66186
Human; Mouse; Rat
WB
KD-Validated Proliferating Cell Nuclear Antigen Rabbit mAb
6151
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F
Sirtuin 2 Rabbit mAb
67362
Human, mouse
WB

RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Aryl Hydrocarbon Receptor Nuclear Translocator Rabbit mAb
1657
Human, mouse, rat
WB
KD-Validated DNA Methyltransferase 3 Alpha Rabbit mAb
2531
Human, Mouse
WB
KD-Validated Euchromatic Histone Lysine Methyltransferase 2 Rabbit mAb
2352
Human
WB, IC
ETS Proto-Oncogene 1, Transcription Factor Rabbit mAb
62771
Human, mouse
WB, IHC
KD-Validated Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Rabb...
2932
Human, mouse, rat, cow, dog, chicken, pig
WB, IC
FosB Proto-Oncogene, AP-1 Transcription Factor Subunit Rabbit mAb
62571
Human, mouse, rat
WB, IHC
KD-Validated Forkhead Box O1 Rabbit mAb
2551
Human, mouse, rat
WB
Forkhead Box O4 Rabbit mAb
62584
Human, mouse
WB
KD-Validated GATA Binding Protein 3 Rabbit mAb
3173
Human, mouse, rat
IC
KD-Validated Histone Deacetylase 4 Rabbit mAb
3214
Human, mouse, rat
WB
KD-Validated Hypoxia Inducible Factor 1 Subunit Alpha Rabbit mAb
3321
Human
WB, IC, F
Interferon Regulatory Factor 7 Rabbit mAb
63627
Human, mouse
WB, IHC
KD-Validated Jun Proto-Oncogene Rabbit mAb
4750
Human, mouse, rat
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
4171
Human, mouse, rat
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
84171
Human
WB
Kruppel Like Factor 4 Rabbit mAb
64424
Human, mouse
WB, IHC
KD-Validated Nuclear Factor Kappa B Subunit 1 Rabbit mAb
85241
Human, mouse, rat, cow, dog, chicken, pig
WB, IHC
KD-Validated Nuclear Receptor Subfamily 3 Group C Member 1 Rabbit mAb
5911
Human, mouse, rat, cow, dog
WB, IC, F
Paired Box 6 Rabbit mAb
66186
Human; Mouse; Rat
WB
KD-Validated Retinoic Acid Receptor Gamma Rabbit mAb
6132
Human, mouse, rat
WB, IC
REL Proto-Oncogene, NF-KB Subunit Rabbit mAb
66240
Human
WB, IHC
KD-Validated RELA Proto-Oncogene, NF-KB Subunit Rabbit mAb
6241
Human, mouse
WB
RELB Proto-Oncogene, NF-KB Subunit Rabbit mAb
66241
Human
WB, IHC
KD-Validated RUNX Family Transcription Factor 1 Rabbit mAb
6751
Human
WB
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB
SMAD Family Member 1 Rabbit mAb
67511
Human, mouse
WB
KD-Validated SMAD Family Member 2 Rabbit mAb
7522
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F
SMAD Family Member 3 Rabbit mAb
67523
Human, mouse
WB, IHC
KD-Validated SMAD Family Member 4 Rabbit mAb
7524
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F
SMAD Family Member 5 Rabbit mAb
67515
Human; Mouse
WB, IHC
KD-Validated Signal Transducer And Activator Of Transcription 3 Mouse mAb
7713
Human, mouse, rat, cow, dog, pig
WB, IC, F

Damaged DNA Binding

Protein Name
Item name
Catalog No.
Reactivity
Applications
Damage Specific DNA Binding Protein 1 Rabbit mAb
62211
Human, mouse
WB, IHC
Damage Specific DNA Binding Protein 2 Rabbit mAb
62212
Human
WB, IHC
High Mobility Group Box 1 Rabbit mAb
63531
Human, mouse
WB, IHC
KD-Validated MutS Homolog 2 Rabbit mAb
5732
Human, mouse, rat, cow, dog, pig
WB, IC, F
KD-Validated Proliferating Cell Nuclear Antigen Rabbit mAb
6151
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F

Chromatin DNA Binding

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Beta-actin Rabbit mAb
1171
Human, mouse, rat
WB, IC, F
Beta-Actin Mouse mAb
1170
Human, mouse, rat, cow, dog, chicken, pig
WB
Beta-Actin Rabbit mAb
9171
Human, mouse, rat, cow, dog, chicken, pig
WB
KD-Validated Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Rabb...
2932
Human, mouse, rat, cow, dog, chicken, pig
WB, IC
KD-Validated Lysine Demethylase 3B Rabbit mAb
4231
Human
WB
KD-Validated RELA Proto-Oncogene, NF-KB Subunit Rabbit mAb
6241
Human, mouse
WB
SMAD Family Member 3 Rabbit mAb
67523
Human, mouse
WB, IHC
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin,...
67512
Human, mouse, rat
WB, IHC
KD-Validated Signal Transducer And Activator Of Transcription 3 Mouse mAb
7713
Human, mouse, rat, cow, dog, pig
WB, IC, F

Chromosomal Region

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Death Domain Associated Protein Rabbit mAb
2188
Human, mouse, rat
WB
Damage Specific DNA Binding Protein 1 Rabbit mAb
62211
Human, mouse
WB, IHC
KD-Validated DNA Methyltransferase 3 Alpha Rabbit mAb
2531
Human, Mouse
WB
KD-Validated Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Rabb...
2932
Human, mouse, rat, cow, dog, chicken, pig
WB, IC
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
4171
Human, mouse, rat
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
84171
Human
WB
Lysine Acetyltransferase 7 Rabbit mAb
64177
Human, mouse, rat
WB
KD-Validated Minichromosome Maintenance Complex Component 7 Rabbit mAb
5157
Human, mouse, rat, cow, dog, pig
WB, IC
KD-Validated MutS Homolog 2 Rabbit mAb
5732
Human, mouse, rat, cow, dog, pig
WB, IC, F
KD-Validated Poly(ADP-Ribose) Polymerase 1 Rabbit mAb
6161
Human, mouse, rat, chicken, pig
WB, IC, F
KD-Validated Proliferating Cell Nuclear Antigen Rabbit mAb
6151
Human, mouse, rat, cow, dog, chicken, pig
WB, IC, F
KD-Validated Protein Phosphatase 2 Catalytic Subunit Alpha Rabbit mAb
6211
Human, mouse, rat
WB
KD-Validated Protein Phosphatase 2 Scaffold Subunit Aalpha Rabbit mAb
6621
Human, mouse, rat, cow, dog, pig
WB
Sirtuin 2 Rabbit mAb
67362
Human, mouse
WB
KD-Validated Sirtuin 6 Rabbit mAb
7366
Human
IC

Euchromatin

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Catenin Beta 1 Rabbit mAb
1711
Human, mouse, rat
WB, IC, F
KD-Validated DNA Methyltransferase 3 Alpha Rabbit mAb
2531
Human, Mouse
WB
KD-Validated Janus Kinase 2 Rabbit mAb
4142
Human, mouse, rat
IC, F
KD-Validated Jun Proto-Oncogene Rabbit mAb
4750
Human, mouse, rat
WB
Kruppel Like Factor 4 Rabbit mAb
64424
Human, mouse
WB, IHC
KD-Validated Ring Finger Protein 2 Rabbit mAb
6522
Human, mouse, rat
IC
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB

Histone Acetyltransferase Complex

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Beta-actin Rabbit mAb
1171
Human, mouse, rat
WB, IC, F
Beta-Actin Mouse mAb
1170
Human, mouse, rat, cow, dog, chicken, pig
WB
Beta-Actin Rabbit mAb
9171
Human, mouse, rat, cow, dog, chicken, pig
WB
KD-Validated Lysine Acetyltransferase 2A Rabbit mAb
4172
Human, mouse, rat, cow, dog, chicken, pig
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
4171
Human, mouse, rat
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
84171
Human
WB
Lysine Acetyltransferase 7 Rabbit mAb
64177
Human, mouse, rat
WB
Mitogen-Activated Protein Kinase Kinase Kinase 7 Rabbit mAb
65167
Human, mouse, rat
WB
KD-Validated O-GlcNAc Transferase Rabbit mAb
85370
Human, mouse, rat, cow, dog, pig
WB

Transcription Coregulator Activity

Protein Name
Item name
Catalog No.
Reactivity
Applications
KD-Validated Prohibitin Rabbit mAb
6310
Human, mouse, rat, cow, dog, chicken, pig
WB
KD-Validated Protein Tyrosine Phosphatase Non-Receptor Type 14 Rabbit mAb
6714
Human, mouse, rat
WB
Paxillin Rabbit mAb
66860
Human; Mouse
WB, IHC
Ring Finger Protein 20 Rabbit mAb
66520
Human; Mouse; Rat
WB
KD-Validated Sirtuin 1 Rabbit mAb
7361
Human, mouse, rat, cow, chicken, pig
IC, WB
KD-Validated Sirtuin 6 Rabbit mAb
7366
Human
IC
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin,...
67512
Human, mouse, rat
WB, IHC
KD-Validated ABL Proto-Oncogene 1 Rabbit mAb
1141
Human
WB
KD-Validated Ajuba LIM Protein Rabbit mAb
1411
Human
WB
KD-Validated Complement C1q Binding Protein Rabbit mAb
81166
Human
WB
KD-Validated Complement C1q Binding Protein Rabbit mAb
1166
Human, mouse, rat, cow (weak), dog
WB, IC
KD-Validated Cyclin D1 Rabbit mAb
1151
Human, mouse, rat
WB
KD-Validated Cyclin D1 Rabbit mAb
81151
Human, Mouse, Rat
WB
KD-Validated Catenin Beta 1 Rabbit mAb
1711
Human, mouse, rat
WB, IC, F
KD-Validated Death Domain Associated Protein Rabbit mAb
2188
Human, mouse, rat
WB
KD-Validated DNA Methyltransferase 3 Alpha Rabbit mAb
2531
Human, Mouse
WB
KD-Validated Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit Rabb...
2932
Human, mouse, rat, cow, dog, chicken, pig
WB, IC
KD-Validated Histone Deacetylase 3 Mouse mAb
3213
Human, mouse, rat, cow, dog
WB, IC
KD-Validated Histone Deacetylase 4 Rabbit mAb
3214
Human, mouse, rat
WB
KD-Validated Histone Deacetylase 7 Rabbit mAb
3217
Human
IC
High Mobility Group Box 1 Rabbit mAb
63531
Human, mouse
WB, IHC
KD-Validated Lysine Acetyltransferase 2A Rabbit mAb
4172
Human, mouse, rat, cow, dog, chicken, pig
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
4171
Human, mouse, rat
WB
KD-Validated Lysine Acetyltransferase 2B Rabbit mAb
84171
Human
WB
Lysine Acetyltransferase 7 Rabbit mAb
64177
Human, mouse, rat
WB
KD-Validated Lysine Demethylase 3B Rabbit mAb
4231
Human
WB