The composition and spatial organization of chromatin are critical for the regulation of gene expression in eukaryotes. The local chromatin environment and the high-order chromatin organization not only determine the accessibility of DNA to transcription factors and RNA polymerase, but also define the spatial proximity between the DNA regulatory elements. In recent years epigenetics, a term referring to modification of histone proteins such as methylation-demethylation and acetylation-deacetylation, has received increasing interests, largely because epigenetics has been linked to human diseases, including, but not limited to, autoimmune disease, behavior plasticity, neurodegenerative and psychological disorder, cancer, and addiction. At Genuine Biotech, we provide high-quality antibodies and knockdown validated lentiviral shRNAs to help you investigate the biochemical mechanisms of chromatin organization and epigenetics.